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490 Fang found DOX increased Nrf2 nuclear accumulation, promoted the expression of HO-1, and caused heme degradation, and led to the rapid and systematic accumulation of free non-heme iron

Consistent with this notion, it has been reported that ER can negatively regulate the level of transferrin receptor TFRC, enhancing the resistance of ER+ breast cancer cells to ferroptosis [22]

It is important to adhere to both dates for safety and efficacy

We observed that Nlrp3 / macrophages present an intrinsically protective redox state and this could be the reason why macrophages did not produce ROS after sUA+LPS stimulus

TRT helps selected patients and requires careful monitoring