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Different effects of intraperitoneal and subcutaneous insulin administration on the GH-IGF-1 axis in type 1 diabetes

124126 The design concept of these multi-agonists is to simultaneously regulate multiple key metabolic pathways to achieve more effective control over blood sugar, body weight, and overall metabolic health

Physiol Behav 283: 114622

Confusion with Growth Hormone and Secretagogues Growth hormone: Acts systemically Alters IGF-1 signaling Can downregulate receptors over time Growth hormone secretagogues: Stimulate pituitary GH release Rely on receptor activation Can lose effectiveness if overstimulated AOD-9604 does neither

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