EClinicalMedicine 58 , 101882 (2023)
Pregnancy: not recommended
Build to nightly application over 2 to 3 weeks
In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition
The benzyl alcohol inhibits the growth of most common bacteria, which allows the same vial to be punctured multiple times across a research protocol without rapid microbial colonisation a key practical advantage over plain sterile water for injection (SWFI)
Wound Healing Signaling: Experimental models utilize GHK-Cu to observe the acceleration of tissue repair