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In vitro studies using A42-treated neuronal cultures have demonstrated upregulation of nuclear receptor coactivator 4 (NCOA4), indicating activation of the ferritinophagy pathway

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While weight loss can improve fertility, GLP-1RAs pose potential teratogenic risks, with animal studies suggesting decreased foetal survival and possible congenital defects [11]

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Kieffer et al Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

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