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MC1R is a G-protein-coupled receptor expressed primarily on melanocytes

The poly (ADP-ribose) polymerase olaparib has been demonstrated to promote ferroptosis in ovarian cancer cells by downregulating SLC7A11 expression (Hong et al., 2021)

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Our study suggests that IGF-1R activation may rescue apoptotic cell death of GNE deficient cell lines and has potential as therapeutic target

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