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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

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271,272 In one randomized controlled trial, 84 postmenopausal women experiencing at least two moderate-to-severe hot flashes daily were assigned to eat a low-fat vegan diet (that included cooked soybeans) or make no dietary change

It is believed that there is an increased risk of cross-reactions with other drugs that contain this functional group in their structure

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