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These inconsistencies may be due to the small sample size of the included studies, differences in baseline characteristics of study participants, differences in study design such as follow-up duration or control group, and other factors

Using that as a template, the first GLP-1 agonist was created and approved for the treatment of diabetes about 20 years ago

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Combining GLP-1 receptor agonists and SGLT-2 inhibitors for cardiovascular disease prevention in type 2 diabetes: A systematic review with multiple network meta-regressions