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The low constant of dissociation for the NADPH suggests that the reaction can be a very efficient controller, acting as a feedback, which would regulate the enzymatic activity

Therefore, it is considered that the dosing strategy can be further optimized (Table 1)

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Future research may focus on further exploring the structureactivity relationship of NRF2 activators, identifying more effective and selective compounds, and studying the potential therapeutic applications of these activators in different disease models