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In animal research, early angiogenic and lesion-reduction markers appear within days, with connective-tissue phases playing out over roughly 4-8 weeks

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Examples of drugs that are in the latter class include the anti-malarial drugs dapsone and primaquine, as well as rasburicase which is normally used in the treatment tumor lysis syndrome in patients undergoing chemotherapy for hematologic cancers, but has also been used to reduce the hyperuricemia associated with gout

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