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At the same time, brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the serum were also increased, indicating that acupuncture has neuroprotective effects (Xiong et al., 2020)

Hence ROS-induced decline in circulatory NO secondary to endothelial dysfunction impairs the growth of the capillary network and blood flow regulation and subsequent diminution of microcirculation in metabolically active tissues and dysregulations of glucose and dyslipidaemia

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