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This is completely normal and safe with proper technique

In yeast, Fis1 interacts with the ligand protein Mdv1 to promote the synthesis and assembly of Drp1-GTP oligomers, which are involved in the regulation of mitochondrial asymmetric fission (Frieden et al., 2004)

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In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

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