what is semaglutide mechanism of action (Wegovy®) The expanding role of semaglutide:

Common Medications Januvia (Sitagliptin) Galvus (Vildagliptin) Galvus Met (Vildagliptin + Metformin) Trajenta (Linagliptin) Onglyza (Saxagliptin) Nesina (Alogliptin) Indications Management of Type 2 Diabetes Mellitus Can be used alone or in combination with other agents (e.g., Metformin) Ideal for patients who want to avoid hypoglycemia or weight gain Side Effects Mild headache or dizziness Minor gastrointestinal discomfort Rarely: pancreatitis or respiratory infections Contraindications Patients with pancreatitis or pancreatic tumors Severe renal impairment (dose adjustment may be required) Pregnant or breastfeeding women DPP-4 inhibitors are an excellent choice for patients who aim for: Stable blood sugar control No sudden hypoglycemia No weight gain But like all diabetes medications, they must be used under medical supervision to ensure proper dosing and monitoring

Fahey, R

hepatic glucose production

In microdosing, a sub-0.25 mg dose is the destination

GIP + GLP-1 work together on two powerful fronts, helping your body regulate blood sugar while optimizing how it stores and burns fat

Conclusion GLP-1 RAs are emerging as a particularly promising class of drugs for the targeted treatment of obese patients with HFpEF