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Studies show that patients tend to regain weight when treatment stops, which is why maintaining weight loss after tirzepatide requires sustained lifestyle changes

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Addition to a GLP-1 RA medication occurred for 9.0% of patients

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The first half of 2025 has confirmed a seismic shift in the pharmaceutical landscape: GLP-1 receptor agonists a class of new drug therapies for diabetes and obesity now dominate global sales charts

Similarly, a recent semaglutide study demonstrated improved muscle composition and functionality , with hand-grip strength increasing by approximately 4 kg over 12 months evidence that muscle tone and performance can improve even as body weight declines