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The guideline language addresses therapeutic GH, not secretagogues, but the mechanistic concern is parallel
It would be a waste of the peptide's sophisticated signaling capability
and tesamorelin for HIV-associated lipodystrophy
doi: 10.3390/nu12092795, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article
Prior to this the drug, approved for diabetes, had often been prescribed off-label for weight loss
Succinate, a key intermediate of the TCA cycle, tends to accumulate in mitochondria under ischemic conditions when the electron transport chain slows due to reduced oxygen availability 54
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