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The expression of the integrin lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) in nave macrophage sEVs mediated the uptake of exosomes in brain endothelial cells, thereby helping sEVs deliver brain-derived neurotrophic factor (BNDF) to the brain, especially in the presence of brain inflammation

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