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Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful ageing

The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

Both temperature and behavioral changes in all these experiments were counteracted by gastric pentadecapeptide BPC 157

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However, when the physiological demand for antioxidants surpasses their bioavailability, the brain enters a state of REDOX imbalance in which ROS accumulate, leading to neuronal damage [6, 7]

It means patients should avoid self-experimentation, unverified online products, and unsupervised dosing