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Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)

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Mechanistic Focus in Research Within experimental laboratory settings, AOD-9604 is commonly studied in relation to peptide-mediated signalling pathways

So, the toning down of inflammation should, help reduce gut oxygen levels further and create a virtuous cycle

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