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doi: 10.1007/s00395-021-00873-9 39 YangXQiangQLiNFengPWeiWHolscherC

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Surface staining efficiency was determined by counting nuclei and Alexa 647-stained cells in five random images per well

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MOTS-c Pathway (Systemic Energy Sensor): Cellular Stress / Exercise Mitochondria release MOTS-c Travels to Nucleus Activates AMPK Result: Increased Insulin Sensitivity + Enhanced ATP Production + Systemic Fat Oxidation 5-Amino-1MQ Pathway (Targeted Fat Burner): High-Fat Diet / Aging 5-Amino-1MQ enters Adipocytes (Fat Cells) Blocks NNMT Enzyme Result: NAD+ Levels Skyrocket Forced Lipolysis (Fat Burning) + Prevention of Fat Storage Why MOTS-c Might Be "Better" Experimental findings show that MOTS-c provides broad, systemic metabolic benefits

If planning pregnancy, discontinue treatment at least 2 months before attempting to conceive