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Its receptor, GLP-1R is a member of class B GPCRs (G protein-coupled receptors) which are characterized by a seven transmembrane domain at their C-termini and a large extra-cellular domain at their N-termini 27,28,29,30

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On the other hand, Wegovy (brand name for semaglutide), approved by FDA recently for chronic weight management along with dietary changes and physical activity, has shown substantial efficacy in reducing body weight as it influences eating patterns centrally leading to decreased calorie intake

A disrupted redox balance, particularly elevated oxidized glutathione (GSSG), is implicated in brain aging and neurodegeneration

doi: 10.1016/j.brainres.2023.148371 29