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Separately, if tachyphylaxis is a limiting factor for GLP1 agonist therapeutic efficacy, identifying and avoiding molecular events that underpin GLP1 receptor desensitisation and/or downregulation may be a fruitful approach

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NT-proBNP was determined in undiluted serum using an ELISA assay according to the manufacturers recommendations (abx576280, Hlzel Diagnostika, Cologne, Germany)