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Additionally, improved glycemic control with GLP-1 RAs in T2DM patients may reduce glycosuria, a process known as glycemic buffering, which reduces caloric loss through urine and offsets part of the energy deficit induced by treatment [43,44,45]

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Continuous stimulation has been theorized to lead to receptor desensitization, whereas intermittent signaling may preserve responsiveness

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." (Emphasis added.) Had the dogs in the study not undergone those tests our results would have been (justifiably) doubted by our peers because the severity of the recruited dogs' heart disease would not have been known In a June 2022 article, Dr

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Finally, the increase in Ins observed in the PFC of the WKY/CMS group is consistent with a previous study in SpragueDawley rats using the forced swim test (FST) model, which reported elevated Ins in the left dorsolateral PFC 88 , although our PFC voxel encompassed the prefrontal cortex without hemispheric subdivision

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doi:10.1007/s13300-020-00816-y 7

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