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The dose response extends beyond weight loss to metabolic parameters

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Sustained elevation of IGF-1 is associated, in observational studies of acromegaly (a disease of GH excess), with increased risk of several cancers including colorectal and breast

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This prevents muscle loss during rapid weight loss

The results, albeit with small numbers of subjects overall, suggest a significant reduction of Lp(a) levels following oral supplementation with L-carnitine