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For candidate drugs Jingfang Granules that have not been thoroughly explored in the field of OA, standardized OA mouse models should be used for rigorous pharmacodynamic validation

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Specifically, the inhibition of Nrf2 ubiquitination increases nuclear Nrf2 retention and ARE-Nrf2 binding affinity (Rizvi et al., 2015a)

[60] Although it is important in catabolism, NADH is also used in anabolic reactions, such as gluconeogenesis

Nature Medicine 2003

doi:10.1016/j.jpba.2011.07.030 Skibiski R (2012a) Photostability study and identification of photodegradation products of ziprasidone by UHPLC-DAD/ESI-Q-TOF