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For a full discussion of the development of the multiple imaging composite APC methodology, we refer readers to the CY 2009 OPPS/ASC final rule with comment period (73 FR 68559 through 68569)

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Extracellular Matrix (ECM) Remodeling Increases synthesis of: Collagen Elastin Glycosaminoglycans Proteoglycans Regulates metalloproteinases for balanced tissue remodeling

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