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This reduction in sample size should be taken into consideration when interpreting the tirzepatide-related outcomes

X-FZ critically revised the manuscript

Extended data figures and tables Extended Data Fig

The initial decrease in testosterone is considered a temporary, adaptive response to rapid weight loss and caloric deficit

While the number on the scale may seem better because you have lost weight, your body will be in a much worse position later, and it will be more challenging to keep weight off or lose it again as you age