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In triple-negative breast cancer, a very aggressive disease with a poor prognosis, the commensal microbiota Clostridiales and its metabolite trimethylamine-N-oxide (TMAO) colonize the mammary gland, being more abundant in tumors exhibiting an activated immune microenvironment (237)

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The loss of NCOA4 significantly abolishes ferritinophagy caused by I/R injury, thus inhibiting ferroptosis

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