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The effects of the GIP and GLP-1 that our body naturally produces only last around two minutes

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E., Christopoulos, A., Miller, L

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Y., Granda, R., Mohan, S., Kuipers, J., Baylink, D., & Veldhuis, J

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GLP-1 receptor activation in the hypothalamus reduces appetite signaling by modulating neuropeptide Y and POMC neurons, while peripheral GLP-1 receptors in the stomach slow gastric emptying by 3040%, creating earlier satiety

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