Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough
Unlike some medications that require careful scheduling to avoid interactions, these two treatments can theoretically be administered on the same day without compromising safety or efficacy
These stimuli are foreign substances and the purpose of the sympathetic nervous system activation may be to protect the host from foreign substances
doi: 10.1007/s00394-022-02959-z
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Though again, you may be able to pay as little as $25 for a month, depending on your insurance