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Modulation of amyloid precursor protein cleavage by cellular sphingolipids

Identification of two related pentapeptides from the brain with potent opiate agonist activity

A. V. Arutjunyan, I. G. Popovich, L. S. Kozina, and G. A. Ryzhak, Peptide Regulation of Ageing: From Experiment to Practice, Bentham Science Publishers Ltd., Feb. 2025. doi: 10.2174/0118746098346230250116065407

A long-term efficacy study published in the Journal of Headache Pain in 2018, that followed patients for two years showed similar results

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Its structure is the cyclic peptide Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH