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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

KT-K declared that they were an editorial board member of Frontiers, at the time of submission

Available at: 12 Garca-CasaresNGonzlez-GonzlezGde la Cruz-CosmeCGarzn-MaldonadoFJde Rojas-LealCArizaMJet al

SCFAs can enhance insulin sensitivity and stimulate GLP-1 secretion (100) and regulate metabolic gene expression by inhibiting histone deacetylase (HDAC) (101)

Gastrointestinal side effects remain a concern

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