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Digestive Issues Women with Lipedema already have higher rates of: IBS Constipation Bloating SIBO (small intestinal bacterial overgrowth) Slow digestion GLP-1s slow gastric emptying even further, which can increase: Constipation Gastroparesis Reflux Nausea If digestive issues are present, they ideally should be addressed before starting GLP-1s

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It was reported that CEO can potentially reduce inflammation by suppressing cyclooxygenase action [76]

Our findings may have implications for choice of glucose-lowering therapy in patients with diabetes mellitus and higher risk of dementia