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Endocr Rev 1999;20:876913.ArticlePubMed 78

These results suggest that PFOS can induce the autophagy-associated apoptosis involved in mitophagy activation

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LLY also announced in mid-February 2024 that a phase 2 trial evaluating tirzepatide for liver disease metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), met its primary endpoint where up to 74% of participants achieved resolution of MASH with no worsening of fibrosis, compared to 13% on placebo

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