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Transdermal delivery of GLP-1 medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function

Bloodwork improvements often appear months before the visual transformation

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The 5 mg designation typically refers to a titrated dose used in clinical studies or investigational protocols

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This quick-reference table helps set patient expectations: nausea is common but often transient, and titration and supportive care usually shorten the course