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The medication has a half-life of approximately one week, meaning steady-state concentrations are reached after four to five weeks of consistent dosing

After 2 weeks of treatment, the dose should be increased to 0.2 mg (100 l) three times daily

Obes (Silver Spring Md) 29(12):20262034 Kolotkin RL, Gadde KM, Peterson CA, Crosby RD (2016) Health-related quality of life in two randomized controlled trials of phentermine/topiramate for obesity: what mediates improvement

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