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Iowa IV
The medication is administered once weekly via subcutaneous injection using a pre-filled pen device, available in doses of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg, allowing for gradual dose escalation to optimise tolerability
The key objective of SOUL was to demonstrate that oral semaglutide lowers the risk of major adverse cardiovascular events (a composite endpoint consisting of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) compared to placebo, both added to standard of care in patients with type 2 diabetes and established CVD and/or CKD
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These assessments typically involve controlled laboratory models where researchers monitor circulating levels of hormones such as cortisol, prolactin, ACTH, and GH
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