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The main adverse effects described in clinical trials employing tirzepatide were gastrointestinal, such as nausea, diarrhea, decreased appetite, delayed gastric emptying, vomiting, acid reflux, and constipation (57)

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In erythroleukemia K562 cells, in addition to the above identified NRF2 binding ARE motif, there is also a strong association of active histone codes (such as H3K4Me3, H3K9Ac, H3K27Ac, H3K79Me2) upstream of the transcription start site (Supplementary Fig

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Their secondary exposure metric was obtained via quantification of APAP dosage in prescription dispensations during pregnancy

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