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A new study published in JAMA Internal Medicine examines the safety of glucagon-like peptide 1 (GLP-1) receptor agonists, along with other second-line medications used in managing diabetes in early pregnancy

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doi:10.1016/S0140-6736(23)01053-X PubMed: This trial evaluated retatrutide in 281 participants with type 2 diabetes, showing up to 16.94% weight loss and significant HbA1c reductions with favorable safety profile comparable to other GLP-1 based therapies

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Lupus 23 , 255262 (2014)

Quick Answer: Insomnia is not listed as a common side effect of tirzepatide in FDA prescribing information or major clinical trials, though some patients report sleep disturbances that may be indirectly related to gastrointestinal symptoms or metabolic changes