Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine
B12 injections are medically indicated for individuals with a diagnosed B12 deficiency or conditions that impair B12 absorption, such as pernicious anemia, Crohns disease, celiac disease, or a history of gastric bypass surgery
May help overcome weight loss plateaus when paired with a healthy lifestyle
To directly feed the heme-biosynthesis pathway, measure mitochondrial respiration, and trace metabolic flux in cellular and animal models
(NOTE: The results were replicated in a separate study using a different NNMT inhibitor, also observing the normalization of tolerance to glucose and increased insulin sensitivity) Already, were seeing some strong interest in using 5-Amino 1MQ to treat obesity and other metabolic diseases in US veterans
Hofer LJ, Elian KM
