Inflammation & Joint Health Clinical Interest Weight reduction reduces mechanical load on joints which alone can ease symptoms of arthritis
Even though it is not recommended, people often stop taking GLP-1 drugs for various reasons, causing them to regain the weight they lost with the medication
Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]
Given the short half-life of endogenous GLP-1, local vagal signaling likely mediates the effect of intestinal GLP-1 release on food intake as well 123
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Biochem Biophys Res Commun 2015;466:33-9.ArticlePubMed 35
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