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The declining plasma concentration provides a quantitative framework for researchers designing dose-response studies, as physiologically relevant in vitro concentrations should bracket the 200-500 nM range to model the young-to-aged spectrum
Improving HTY stability and exposure profiles may be possible through novel formulation strategies such as nanotechnology-based delivery systems and the development of functional foods designed for targeted delivery
It has been identified that these mitophagy receptors can directly interact with the autophagy mediators LC3/GABARAP via a conserved LC3-interacting region (LIR) motif or ULK1 protein to form the nascent autophagosome
neuroinflammation further impairs neuronal mitochondrial function and synaptic plasticity, exacerbating central energy deficiency and interoceptive dysregulation
The various plant extracts and their phytoconstituents designed as nanostructured particulates with their therapeutic application are highlighted in Table 2
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