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Functional enrichment (GO/KEGG) and Gene Set Enrichment Analysis (GSEA) revealed that GGCT knocking down significantly impacted pathways related to the cell cycle, oxidative stress, cell proliferation, and cell death in both cancers (Fig

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MiRNAs such as miR-526b and miR-578 regulate the expression of RAAS components, which not only exacerbate hypertension but may also influence tumor cell drug resistance and invasiveness, thereby further promoting the progression of lung cancer [91,92,93,94]

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Chronic inflammation is associated with increased oxidative stress, which arises from the generation of ROS and advanced glycation end products (AGEs) (Ha et al., 2024)