Getting 10,000 to 40,000 IU of vitamin D in a day could lead to acute toxicity
This ROS-driven cascade converges on microvascular dysfunctioncharacterized by dysregulated vasodilation, compromised endothelial barrier function, and increased vascular fragilityultimately manifesting as mucosal erosions and hemorrhage, the hallmark features of PHG [373]
This is dependent upon both your genetics and your environment - those who smoke, laugh or smile more frequently, or who dont protect themselves from the sun, will experience them earlier in life than if they had not had these negative environmental factors
Am J Ind.Med 2000;38(2):115-126
Suppositories are usually safe to use
Cobalt supplementation may be required in some areas where Vitamin B12 deficiency occurs