DSIP (Delta Sleep-Inducing Peptide) is a synthetic nonapeptide: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Further research and clinical trials are needed before possibilities for evidence-based therapeutic applications of gut microbiota metabolites can be identified
Ann Oncol 8 Suppl 2:97-100, 1997
This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL
The peptide has been the subject of multiple in vitro and animal studies (and a smaller number of human observational studies) published in Bulletin of Experimental Biology and Medicine , Biogerontology , and other journals
The solution was then centrifuged for 10 min (12000 rpm, 4C) and centrifuged for 10 min (12000 rpm, 4C)