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On the other hand, IGFBP-3 undergoes augmented proteolysis on diabetic patients which results in a sudden rise of free IGF-1 concentrations [257, 258]

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IGF-1 is insensitive to repetitive freeze-thaw cycles [110,111] and displays only minor circadian fluctuations, negating the need for repetitive standardized sampling procedures as is required with GH due to the pulsatile nature of its release and diurnal variation

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As always, consult with a healthcare professional before taking any supplements

Among them are modulation of inflammation, promotion of angiogenesis, enhancement of matrix remodeling and activation of repair-linked transcription programs