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Recent 2025 treatment guidelines from the American Academy of Sleep Medicine have elevated gabapentinoids like Horizant to first-line status, moving away from older dopamine agonist medications that carry risks of augmentation (worsening of symptoms over time)

In addition, the participants identified as mostly white and female, and further studies in more diverse populations are needed to examine sex and race differences

These side effects can lower libido or make sex less appealing, at least temporarily

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Store vials sealed in an airtight container, ideally with a desiccant pack, and let a cold vial warm to room temperature before opening so condensation doesn't form inside

For chronic conditions or malabsorption: Weekly sessions may be appropriate initially, transitioning to biweekly or monthly as nutrient stores are replenished