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Because bone and joint damage occur later in the course of the disease, X-rays may not be very useful in detecting RA in the early stages, although soft tissue swelling around a joint can be seen on a regular X-ray

Beroukhim, R

After our mid-twenties, individuals naturally lose about 1% of their collagen per year

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It also notes some providers use a shared decision-making model in which the adolescent, the parents, and the clinician review risks, benefits, lifestyle requirements, and cost together rather than the clinician deciding alone