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Prescription tretinoin (the strongest retinoid) has been studied in large-scale randomised controlled trials for decades

Evidence for prolonged release of excitatory amino acids in severe human head trauma

The results showed that cells with suppressed GPX3 expression were more susceptible to cell death induced by ascorbate, indicating that GPX3 expression is crucial for scavenging excessive extracellular H2O2

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The risks: Studies have shown vitamin C in high doses intravenously can change from a protective antioxidant to a potentially damaging pro-oxidant

No claims regarding human therapeutic outcomes are made or implied