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Montgomery, B

Aggregation can lead to reduced yields and complicate downstream analyses

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These data reveal opposing effects of the forward (BMAL1-mediated) and reverse (CRY-mediated) limbs of the intrinsic clock on CI respiration, independent of nutrient availability

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Thus, although an important point to keep attention to, data so far does not indicate that cardiovascular complications are a major cause for concern at the moment (gastrointestinal problems being by far the larger problem experienced by people on GLP1R agonists )