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Binding that receptor on the pituitary and hypothalamus drives a pulse of growth-hormone release

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Three key findings emerged from this study: (1) PRMT1 upregulation in injured TECs drives UBE2m methylation at R169, (2) methylated UBE2m promotes NEDD4 neddylation and subsequent PPAR ubiquitination, and (3) this pathway is clinically relevant in stone patients, correlating with renal function decline