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The specific amount of weight you might lose from Zepbound is uncertain, but significant weight loss ranging from 35.5 lb (16.1 kg) to 52.0 lb (23.6 kg) was observed in the 72-week SURMOUNT-1 clinical trial, which compared different Zepbound (tirzepatide) doses to a placebo (inactive treatment)

Berberine can alleviate cognitive function of Alzheimers disease mice via reducing the hyperphosphorylation of tau and promoting the autophagy clearance of tau (Yu et al., 2011)